OGMA 175

Treatment of respiratory infections due to Pasteurella multocida and Mannheimia
haemolytica, urinary tract infections, skin and soft tissue infections (e.g. abscesses,
pyoderma, anal sacculitis and gingivitis Amoxicillin shows activity against susceptible
Gram positive bacteria and Gram negative bacteria. Beta-lactam antibiotics prevent the
bacterial cell wall from forming by interfering with the final stage of peptidoglycan
synthesis. Clavulanic acid is one of the naturally occurring metabolites of the
streptomycete Streptomyces clavuligerus . It has structural similarity to the penicillin
nucleus, including possession of a beta-lactam ring. Amoxicillin is susceptible to
breakdown by ß-lactamases produced by some bacterial species, and therefore
combination with an effective ß-lactamase inhibitor (clavulanic acid) extends the range
of bacteria against which it is active to include ß-lactamase producing species