IVO-10

IVERMECTIN (ivermectin) is an injectable parasiticide for cattle and swine. One low-volume dose effectively
treats and controls the following internal and external parasites that may impair the health of cattle and
swine: gastrointestinal roundworms (including inhibited Ostertagia ostertagi in cattle), lungworms,
grubs, sucking lice and mange mites of cattle; and gastrointestinal roundworms, lungworms, lice and
mange mites of swine. Ivermectin is a member of the macrocyclic lactone
class of endectocides which have a unique mode of action. Compounds of the class bind selectively and
with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and
muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions
with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated
by the neurotransmitter gamma-aminobutyric acid (GABA).